Toward an Anatomy of Disappointment: Reward-Related Signals from the Globus Pallidus
نویسنده
چکیده
The globus pallidus (internal segment, GPi) is traditionally regarded as part of the motor system. In this issue of Neuron, Hong and Hikosaka report on a little known projection from the monkey GPi to the lateral habenula that is modulated by reward. This adds an important branch to the brain's reward circuitry.
منابع مشابه
The Globus Pallidus Sends Reward-Related Signals to the Lateral Habenula
As a major output station of the basal ganglia, the globus pallidus internal segment (GPi) projects to the thalamus and brainstem nuclei thereby controlling motor behavior. A less well known fact is that the GPi also projects to the lateral habenula (LHb) which is often associated with the limbic system. Using the monkey performing a saccade task with positionally biased reward outcomes, we fou...
متن کاملActivity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata.
The basal ganglia are a subcortical assembly of nuclei involved in many aspects of behavior. Three of the nuclei have high firing rates and inhibitory influences: the substantia nigra pars reticulata (SNr), globus pallidus interna (GPi), and globus pallidus externa (GPe). The SNr contains a wide range of visual, cognitive, and motor signals that have been shown to contribute to saccadic eye mov...
متن کاملDiverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey
The lateral habenula (LHb) plays an important role in motivational decision making. Neurons in the primate LHb signal negative 'reward prediction errors' and inhibit midbrain dopamine (DA) neurons. These negative reward prediction error signals in the LHb are, at least partly, provided by a distinct group of neurons in the border region of the globus pallidus internal segment (GPb). However, it...
متن کاملمعرفی دو عضو یک خانواده مبتلا به بیماری هالروردن- اسپاتز
Hallervorden Spatz Disease is a rare neurodegenerative disorder with the prevalence of one to three per million. The onset of symptoms is usually in late childhood and early adolescence. However, some cases of the disease were reported in adulthood which could be familial or sporadic. The familial cases are autosomal-recessive resulting from mutation in the pantothenate kinase 2 gene located on...
متن کاملA pallidus-habenula-dopamine pathway signals inferred stimulus values.
The reward value of a stimulus can be learned through two distinct mechanisms: reinforcement learning through repeated stimulus-reward pairings and abstract inference based on knowledge of the task at hand. The reinforcement mechanism is often identified with midbrain dopamine neurons. Here we show that a neural pathway controlling the dopamine system does not rely exclusively on either stimulu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuron
دوره 60 شماره
صفحات -
تاریخ انتشار 2008